Dave Feldman and Siobhan Huggins return for the ULTIMATE lipid podcast, the roots of insulin resistance, hs-CRP and Lp(a).

If you are interested in lipids, you’ve probably heard of Dave Feldman and his work. If not,  you’ve got some homework to do, and I think you’ll be amazed at what you find. Dave’s work can found at cholesterolcode.com where he details his multiple, meticulous self-experimental projects. Prior to cholesterol adventures Dave was a senior software scientist and an engineer. He brings this “out of the box” thinking to the world of medicine and we are all better off for it. 

He began a low-carb, high-fat diet in April 2015 and has since learned everything he could about it with special emphasis on cholesterol. He saw his own lipid numbers spike substantially after going on the diet and spotted a pattern in the lipid system that’s very similar to distributed objects in networks.

He’s since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. Where he induced a 73 point drop in my LDL-C and a 1115 point drop in my LDL-P. 

Siobhan (she’-VAUN) Huggins is an independent researcher focused on lipidology, the immune system, and metabolic diseases. She spends most of her time at cholesterolcode.com where she works alongside Dave Feldman. She has been keto since August of 2016, and on a predominantly carnivorous diet as of October 2017. She has lost 80 lbs, reversed hypertension, and found a passion for research along the way.


 Time stamps:

5:47 Dave Feldman’s blood testing at low carb San Diego

7:17 The Feldman Protocol

9:39 Does it matter whether subjects are a ketogenic vs. carbohydrate based metabolism 11:19 What labs were administered?

13:03 Shevawn(Siobhan??) on the inflammatory markers.

14:09 What’s the sense of the half-life of HSCRP?

18:09 Ferritin

22:34 Other Markers being tested?

25:29 Glucagon

27:17 is it expected from these labs to find free fatty acids in the blood ?

29:23 What do you use as a cutoff for high fasting insulin?

30:00: C-Peptide

32:55 Hemaglobin A1C

34:37 Test frequency/pitfalls of looking at tests in isolation.

38:09 The Lipid Panel ,(triglycerides)

42:42 How are Triglycerides different from free fatty acids?

45:22 Measuring Triglycerides. What Happens to triglycerides after eating a high fat Carnivore meal?

50:13 Any utility to non-fasted lipid panels ?

50:52 Will triglycerides be higher on a Ketogenic diet (postprandially)

51:39 difference in postprandial triglycerides between Keto and carbohydrate based metabolisms. 

54:14 Recommendations around Triglycerides.

58:32 What else elevates triglycerides?

1:01:39 Thoughts on Coffee

1:04:56 National Health and Nutritional Survey.

1:06:49 How many people are in this data set?

1:08:15 What is linear regression?

1:11:58 Why Dave wanted to look at all cause mortality.

1:13:52 Ldl and all cause mortality 

1:14:57 Age parity 

1:16:37 “The Dave Dance”

1:17:52 Critique:diseases that bring down LDL.

1:20:59 What epidemiology is useful for.

123:32 What happened when those who died within 10 years.

1:23:22 How many people ended up in the age parity subset?

1:25:20 How could LDL be good for you?

1:31:57 Evolutionary role of insulin resistance.

1:32:14 Insulin Resistance and infections.

1:36:37 Underlying Triggers

1:37:10 Virta program.

1:39:52 Carnivore Diet talk.

1:42:22 Studies on Antioxidants.

1:45:17 Lp(a)

1:50:07 Can you change Lp (a)

1:59:47 What characters would Dave and SIobhan be at Comic Con ?

2:00:42 The most radical thing they did recently